Therapeutic activity of plant-derived alkaloid conophylline on metabolic syndrome and neurodegenerative disease models

Author:

Umezawa KazuoORCID,Kojima Itaru,Simizu Siro,Lin Yinzhi,Fukatsu Hitomi,Koide Naoki,Nakade Yukiomi,Yoneda Masashi

Funder

JSPS Kakenhi

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Cell Biology

Reference34 articles.

1. Kam TS, Loh KY, Wei C. Conophylline and conophyllidine: new dimeric alkaloids from Tabernaemontana divaricata. J Nat Prod. 2008;56:1865–71.

2. Umezawa K, Ohse T, Yamamoto T, Koyano T, Takahashi Y. Isolation of a new vinca alkaloid from the leaves of Ervatamia microphylla as an inhibitor of ras functions. Anticancer Res. 1994;14:2413–7.

3. Umezawa K, Taniguchi T, Toi M, Ohse T, Tsutsumi N, Yamamoto T, et al. Growth inhibition of K-Ras-expressing tumours by a new vinca alkaloid, conophylline, in nude mice. Drugs Exptl Clin Res. 1996;22:35–40.

4. Amino N, Ohse T, Koyano T, Umezawa K. Inhibition of cellular chemotactic invasion by a vinca alkaloid, conophylline. Anticancer Res. 1996;16:55–60.

5. Mashima H, Ohnishi H, Wakabayashi K, Mine Y, Miyagawa J, Hanafusa T, et al. Betacellulin and activin A coordinately convert amylase-secreting pancreatic AR42J cells into insulin-secreting cells. J Clin Investig. 1996;97:1647–54.

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