In vivo system to detect long-term continuous release of bioactive interleukin-2 by immunopharmacological depot preparations in nude mice with human tumors

Author:

Huland Edith,Falk Burkhard,H�bner Dirk,Huland Hartwig

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology,General Medicine

Reference24 articles.

1. Bubenik J, Kieler J, Tromholt, J et al (1986) Recombinant interleukin-2 inhibits growth of human tumor xenografts in congenitally athymic mice. Immunol Lett 14: 325?330

2. Cheever MA, Greenberg PD Irle C, et al (1984) Imerleukin-2 administered in vivo induces the growth of cultured T-cells in vivo. J Immunol 132: 2259?2265

3. Gillis S, Watson J (1981) Interleukin-2 induction of hapten-specific cytotoxic T-cells in nude mice. J Immunol 126: 1245?1248

4. Hosokawa M, Morikawa K, Okada F, et al (1986) An enhaced therapeutic effect in the treatment of rat transplanted tumors by mixing interleukin 2 in a Pluric gel, a sustained-release vehicle. In: Urushizaki I, T. Aoki T, Tsubura E (eds) Host defence mechanisms against cancer. Excerpta Medica, Amsterdam Princeton Hong Kong, pp 26?35

5. Huland E, Huland H (1989) Local continuous high dose interleukin 2: a new therapeutic model for the treatment of advanced bladder carcinoma. Cancer Res 49: 5469?5474

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