Rapamycin increases leukemia cell sensitivity to chemotherapy by regulating mTORC1 pathway-mediated apoptosis and autophagy
Author:
Funder
the National Natural Science Foundation of China
Jiangxi "5511" Science and Technology Innovation Talent Project
Publisher
Springer Science and Business Media LLC
Link
https://link.springer.com/content/pdf/10.1007/s12185-024-03732-0.pdf
Reference38 articles.
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2. Li G, Zhou Z, Yang W, Yang H, Fan X, Yin Y, et al. Long-term cardiac-specific mortality among 44,292 acute myeloid leukemia patients treated with chemotherapy: a population-based analysis. J Cancer. 2019;10(24):6161–9. https://doi.org/10.7150/jca.36948.
3. Stetson LC, Balasubramanian D, Ribeiro SP, Stefan T, Gupta K, Xu X, et al. Single cell RNA sequencing of AML initiating cells reveals RNA-based evolution during disease progression. Leukemia. 2021;35(10):2799–812. https://doi.org/10.1038/s41375-021-01338-7.
4. Stengel S, Petrie KR, Sbirkov Y, Stanko C, Ghazvini Zadegan F, Gil V, et al. Suppression of MYC by PI3K/AKT/mTOR pathway inhibition in combination with all-trans retinoic acid treatment for therapeutic gain in acute myeloid leukaemia. Br J Haematol. 2022. https://doi.org/10.1111/bjh.18187.
5. Bou-Tayeh B, Laletin V, Salem N, Just-Landi S, Fares J, Leblanc R, et al. Chronic IL-15 stimulation and impaired mTOR signaling and metabolism in natural killer cells during acute myeloid leukemia. Front Immunol. 2021;12:730970. https://doi.org/10.3389/fimmu.2021.730970.
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