Intracellular Ca2+ in pancreatic acinar cells: Regulation and role in stimulation of enzyme secretion-Reference-Cited by-同舟云学术

Intracellular Ca2+ in pancreatic acinar cells: Regulation and role in stimulation of enzyme secretion

Published:1987-04-01 Issue:4 Volume:7 Page:333-344
ISSN:0144-8463
Container-title:Bioscience Reports
language:en
Short-container-title:

Author:

Dormer Robert L.¹,Brown Graham R.¹,Doughney Claire¹,McPherson Margaret A.¹

Affiliation:

1. Department of Medical Biochemistry, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, UK

Abstract

Evidence for a primary role for intracellular Ca2+ in the stimulation of pancreatic enzyme secretion is reviewed. Measurements of cytoplasmic free Ca2+ concentration have allowed direct demonstration of its importance in triggering enzyme secretion and defined the concentration range over which membrane Ca2+ pumps must work to regulate intracellular Ca2+. Current evidence suggests a key role for the Ca2+ Mg-ATPase of rough endoplasmic reticulum in regulating intracellular Ca2+ and accumulating a Ca2+ store which is released by the action of inositol-l,4,5 trisphosphate following stimulation of secretion.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Link

https://portlandpress.com/bioscirep/article-pdf/7/4/333/472050/bsr0070333.pdf

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