Phase II trial of PALA and 6-methylmercaptopurine riboside (MMPR) in combination with 5-fluorouracil in advanced pancreatic cancer

Author:

Redei Istvan,Green Fran,Hoffman John P.,Weiner Louis M.,Scher Richard,O'Dwyer Peter J.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology,Oncology

Reference11 articles.

1. Brennan MF, Kinsella T, Friedman M: Cancer of the pancreas. In: De Vita VT, Heller S, Rosenberg SA (eds): Cancer: Principles and Practice of Oncology (3rd ed). Lippincott, Philadelphia, PA, 1989, pp 800?835

2. Grem JL: Fluorinated pyrimidines. In: Chabner BA, Collins JM (eds): Cancer Chemotherapy: Principles and Practice. Lippincott, Philadelphia, PA, 1990, pp 180?224

3. O'Dwyer PJ: The role of low-dose PALA in biochemical modulation. Pharmac Ther 48:371?380, 1990

4. Martin DS, Stolfi RL, Sawyer RC, Spiegelman S, Young CW: Therapeutic utility of utilizing low doses of N-(phosphonacetyl)-L-aspartic acid in combination with 5-fluorouracil: a murine study with clinical relevance. Cancer Res 43:2317?2321, 1983

5. O'Dwyer PJ, Hudes GR, Colofiore J, Walczak J, Hoffman J, LaCreta FP, Comis RL, Martin DS, Ozols RF: Phase I trial of 5-fluorouracil modulation by PALA and MMPR: optimization of MMPR dose and schedule through biochemical analysis of sequential tumor biopsy specimens. J Natl Cancer Inst 83:1235?1240, 1991

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