Enhanced IL-12p40 production by phenylarsine oxide is mediated by cAMP response element in macrophages
Author:
Publisher
Springer Science and Business Media LLC
Subject
Organic Chemistry,Drug Discovery,Molecular Medicine
Link
http://link.springer.com/content/pdf/10.1007/s12272-010-0514-9.pdf
Reference33 articles.
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2. Frearson, J. A. and Alexander, D. R., The phosphotyrosine phosphatase SHP-2 participates in a multimeric signaling complex and regulates T cell receptor (TCR) coupling to the Ras/mitogen-activated protein kinase (MAPK) pathway in Jurkat T cells. J. Exp. Med., 187, 1417–1426 (1998).
3. Hasko, G. and Szabo, C., IL-12 as a therapeutic target for pharmacological modulation in immune-mediated and inflammatory diseases: regulation of T helper 1/T helper 2 responses. Br. J. Pharmacol., 127, 1295–1304 (1999).
4. Hmadcha, A., Carballo, M., Conde, M., Marquez, G., Monteseirin, J., Martin-nieto, J., Bedoya, F. J., Pintado, E., and Sobrino, F., Phenylarsine oxide increases intracellular calcium mobility and inhibits Ca(2+)-dependent ATPase activity in thymocytes. Mol. Genet. Metab., 68, 363–370 (1999).
5. Iwanaga, K., Yang Y., Raso, M. G., Ma, L., Hanna, A. E., Thilaganathan, N., Moghaddam, S., Evans, C. M., Li, H., Cai, W. W., Sato, M., Minna, J. D., Wu, H., Creighton, C. J., Demayo, F. J., Wistuba, II, and Kurie, J. M., Pten inactivation accelerates oncogenic K-ras-initiated tumorigenesis in a mouse model of lung cancer. Cancer Res., 68, 1119–1127 (2008).
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