Methyl syringate, a low-molecular-weight phenolic ester, as an activator of the chemosensory ion channel TRPA1
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Published:2012-12
Issue:12
Volume:35
Page:2211-2218
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ISSN:0253-6269
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Container-title:Archives of Pharmacal Research
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language:en
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Short-container-title:Arch. Pharm. Res.
Author:
Son Hee Jin,Kim Min Jung,Park Jae-Ho,Ishii Sho,Misaka Takumi,Rhyu Mee-Ra
Publisher
Springer Science and Business Media LLC
Subject
Organic Chemistry,Drug Discovery,Molecular Medicine
Reference40 articles.
1. Andersson, D., TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid Δ9-tetrahydrocannabiorcol. Nat. Commun., 2, 551 (2011). 2. Andrè, E., Campi, B., Materazzi, S., Trevisani, M., Amadesi, S., Massi, D., Creminon, C., Vaksman, N., Nassini, R., Civelli, M., Baraldi, P. G., Poole, D. P., Bunnett, N. W., Geppetti, P., and Patacchini, R., Cigarette smoke-induced neurogenic inflammation is mediated by alpha, beta-unsaturated aldehydes and the TRPA1 receptor in rodents. J. Clin. Invest., 118, 2574–2582 (2008). 3. Bandell, M., Story, G. M., Hwang, S. W., Viswanath, V., Eid, S. R., Petrus, M. J., Earley, T. J., and Patapoutian, A., Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron, 41, 849–857 (2004). 4. Bassoli, A., Borgonovo, G., Caimi, S., Scaglioni, L., Morini, G., Moriello, A. S, Marzo, V. D., and Petrocellis, L. D., Tasteguided identification of high potency TRPA1 agonists from Perilla frutescens. Bioorg. Med. Chem., 17, 1636–1639 (2009). 5. Bautista, D. M., Jordt, S. E., Nikai, T., Tsuruda, P. R., Read, A. J., Poblete, J., Yamoah, E. N., Basbaum, A. I., and Julius, D., TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell, 124, 1269–1282 (2006).
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