In vitro characterization of the enzymes involved in the metabolism of 1-Furan-2-yl-3-pyridin-2-yl-propenone, an anti-inflammatory propenone compound-Reference-Cited by-同舟云学术

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In vitro characterization of the enzymes involved in the metabolism of 1-Furan-2-yl-3-pyridin-2-yl-propenone, an anti-inflammatory propenone compound

Published:2008-06 Issue:6 Volume:31 Page:764-770
ISSN:0253-6269
Container-title:Archives of Pharmacal Research
language:en
Short-container-title:Arch. Pharm. Res.

Author:

Lee Sang Kyu,Kim Ju Hyun,Seo Young Min,Kim Hye Chun Hwa,Kang Mi Jeong,Jeong Hye Gwang,Lee Eung Seok,Jeong Tae Cheon

Publisher

Springer Science and Business Media LLC

Subject

Organic Chemistry,Drug Discovery,Molecular Medicine

Link

http://link.springer.com/content/pdf/10.1007/s12272-001-1224-3.pdf

Reference19 articles.

1. Ahmed, N. K., Felsted, R. L., and Bachur, N. R., Heterogeneity of anthracycline antibiotic carbonyl reductase in mammalian livers. Biochem. Pharmacol., 27, 2713–2719 (1978).

2. Atalla, A. and Maser, E., Carbonyl reduction of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in cytosol of mouse liver and lung. Toxicology, 139, 155–166 (1999).

3. Clement, B., Demesmaeker, M., and Linne, S., Microsomal catalyzed N-hydroxylation of guanabenz and reduction of the N-hydroxylated metabolites: characterization of the two reactions and genotoxic potential of guanoxabenz. Chem. Res. Toxicol., 9, 682–688 (1996).

4. Forrest, G. L. and Gonzalez, B., Carbonyl reductase. Chem. Biol. Interact. 129, 21–40 (2000).

5. Jahng, Y., Zhao, L. X., Moon, Y. S., Basnet, A., Kim, E. K., Chang, H. W., Ju, H. K., Jeong, T. C., and Lee, E. S., Simple aromatic compounds containing propenone moiety show considerable dual COX/5-LOX inhibitory activities. Bioorg. Med. Chem. Lett., 24, 2559–2562 (2004).

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Comprehensive Analysis of in Vivo Phosphoproteome of Mouse Liver Microsomes;Journal of Proteome Research;2015-10-30

2. Reductive metabolism of nabumetone by human liver microsomal and cytosolic fractions: exploratory prediction using inhibitors and substrates as marker probes;European Journal of Drug Metabolism and Pharmacokinetics;2014-03-22

3. Hepatotoxic Effects of 1-Furan-2-yl-3-pyridin-2-yl-propenone, a New Anti-Inflammatory Agent, in Mice;Biomolecules and Therapeutics;2009-07-31

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