Role of metabolism by human intestinal microflora in geniposide-induced toxicity in HepG2 cells-Reference-Cited by-同舟云学术

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Role of metabolism by human intestinal microflora in geniposide-induced toxicity in HepG2 cells

Published:2012-04 Issue:4 Volume:35 Page:733-738
ISSN:0253-6269
Container-title:Archives of Pharmacal Research
language:en
Short-container-title:Arch. Pharm. Res.

Author:

Kang Mi Jeong,Khanal Tilak,Kim Hyung Gyun,Lee Dae Hun,Yeo Hee Kyung,Lee Yong Sup,Ahn Young Tae,Kim Dong Hyun,Jeong Hye Gwang,Jeong Tae Cheon

Publisher

Springer Science and Business Media LLC

Subject

Organic Chemistry,Drug Discovery,Molecular Medicine

Link

http://link.springer.com/content/pdf/10.1007/s12272-012-0418-y.pdf

Reference16 articles.

1. Akao, T., Kobashi, K., and Aburasa, M., Enzymic studies on the animal and intestinal bacterial metabolism of geniposide. Biol. Pharm. Bull., 17, 1573–1576 (1994).

2. Blaut, M., Braune, A., Wunderlich, S., Sauer, P., Schneider, H., and Glatt, H., Mutagenicity of arbutin in mammalian cells after activation by human intestinal bacteria. Food Chem. Toxicol., 44, 1940–1947 (2006).

3. Cao, H., Feng, Q., Xu, W., Li, X., Kang, Z., Ren, Y., and Du, L., Genipin induced apoptosis associated with activation of the c-Jun NH2-terminal kinase and p53 protein in HeLa cells. Biol. Pharm. Bull., 33, 1343–1348 (2010).

4. Gorbach, S. L., Nahas, L., Lerner, P. I., and Weinstein, L., Studies of intestinal microflora. Gastroenterology, 53, 845–855 (1967).

5. Hou, Y. C., Tsai, S. Y., Lai, P. Y., Chen, Y. S., and Chao, P. D. L., Metabolism and pharmacokinetics of genipin and geniposide in rats. Food Chem. Toxicol., 46, 2764–2769 (2008).

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