Synthesis of 2-alkynyl substituted 4′-thioadenosine derivatives and their binding affinities at the adenosine receptors
Author:
Publisher
Springer Science and Business Media LLC
Subject
Organic Chemistry,Drug Discovery,Molecular Medicine
Link
http://link.springer.com/content/pdf/10.1007/s12272-001-1254-x.pdf
Reference8 articles.
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2. Gao, Z.-G., Joshi, B. V., Klutz, A. M., Kim, S. K., Lee, H. W., Kim, H. O., Jeong, L. S., and Jacobson, K. A., Conversion of A3 Adenosine Receptor agonists into selective antagonists by modification of the 5′-ribofuran-uronamide moiety. Bioorg. Med. Chem. Lett. 16, 596–601 (2006).
3. Jacobson, K. A. and Gao, Z.-G., Adenosine receptors as therapeutic targets. Nature Rev. Drug Disc. 5, 247–264 (2006).
4. Jeong, L. S., Lee, H. W., Jacobson, K. A., Kim, H. O., Shin, D. H., Lee, J. A., Gao, Z.-G., Lu, C., Duong, H. T., Gunaga, P., Lee, S. K., Jin, D. Z., Chun, M. W., and Moon, H. R., Structure-activity relationship of 2-chloro-N6-substituted-4′-thioadenosine-5′-uronamides as highly potent and selective agonists at the human A3 adenosine receptor. J. Med. Chem. 49, 273–281 (2006).
5. Jeong, L. S., Lee, H. W., Kim, H. O., Jung, J. Y., Gao, Z.-G., Duong, H. T., Rao, S., Jacobson, K. A., Shin, D. H., Lee, J. A., Gunaga, P., Lee, S. K., Jin, D. Z., Chun, M. W., and Moon, H. R., Design, synthesis, and biological activity of N 6-substituted-4′-thioadenosines at the Human A3 adenosine receptor. Bioorg. Med. Chem. 14, 4718–4730 (2006).
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