Polygonumnolides A1–B3, minor dianthrone derivatives from the roots of Polygonum multiflorum Thunb-Reference-Cited by-同舟云学术

Polygonumnolides A1–B3, minor dianthrone derivatives from the roots of Polygonum multiflorum Thunb

Published:2017-07-05 Issue:6 Volume:41 Page:617-624
ISSN:0253-6269
Container-title:Archives of Pharmacal Research
language:en
Short-container-title:Arch. Pharm. Res.

Author:

Yang Jianbo,Yan Zheng,Ren Jin,Dai Zhong,Ma Shuangcheng,Wang Aiguo,Su Yalun

Abstract

Abstract Seven new dianthrone glycosides, named polygonumnolides A1–B3 (1–7), were isolated from the 70 % EtOH extract of the dried roots of Polygonum multiflorum Thunb. using column chromatography and preparative high-performance liquid chromatography. Their structures were determined by 1D and 2D NMR and mass spectroscopy. The isolated compounds were evaluated for their cytotoxic effects against KB tumor cell lines and compounds 1–4 showed moderate cytotoxicity.

Funder

National Natural Science Foundation of China

The 12th Five Year National significant new drugs creation feature subjects-traditional Chinese medicine quality safety evaluation and risk control technology platform

Publisher

Springer Science and Business Media LLC

Subject

Organic Chemistry,Drug Discovery,Molecular Medicine

Link

http://link.springer.com/article/10.1007/s12272-016-0816-7/fulltext.html

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