Development of Human in vitro Brain-blood Barrier Model from Induced Pluripotent Stem Cell-derived Endothelial Cells to Predict the in vivo Permeability of Drugs-Reference-Cited by-同舟云学术

Development of Human in vitro Brain-blood Barrier Model from Induced Pluripotent Stem Cell-derived Endothelial Cells to Predict the in vivo Permeability of Drugs

Published:2019-05-11 Issue:6 Volume:35 Page:996-1010
ISSN:1673-7067
Container-title:Neuroscience Bulletin
language:en
Short-container-title:Neurosci. Bull.

Author:

Li Yuan,Sun Xueying,Liu Houfu,Huang Liang,Meng Guofeng,Ding Yu,Su Wenji,Lu Jiaqi,Gong Sophie,Terstappen Georg C.,Zhang Ru,Zhang Wandong^ORCID

Publisher

Springer Science and Business Media LLC

Subject

General Medicine,Physiology,General Neuroscience

Link

http://link.springer.com/content/pdf/10.1007/s12264-019-00384-7.pdf

Reference39 articles.

1. Goodwin JT, Clark DE. In silico predictions of blood-brain barrier penetration: considerations to “keep in mind”. J Pharmacol Exp Ther 2005, 315: 477–483.

2. Cho CF, Wolfe JM, Fadzen CM, Calligaris D, Hornburg K, Chiocca EA, et al. Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents. Nat Commun 2017, 8: 15623.

3. Abbott NJ. Prediction of blood-brain barrier permeation in drug discovery from in vivo, in vitro and in silico models. Drug Discov Today Technol 2004, 1:407–416.

4. Liu HF, Dong K, Zhang W, Summerfield SG, Terstappen GC. Prediction of brain-to-blood unbound concentration ratios in CNS drug discovery employing in silico and in vitro model systems. Drug Discov Today 2018, 23: 1357–1372.

5. Eigenmann DE, Xue G, Kim KS, Moses AV, Hamburger M, Oufir M. Comparative study of four immortalized human brain capillary endothelial cell lines, hCMEC/D3, hBMEC, TY10, and BB19, and optimization of culture conditions, for an in vitro blood-brain barrier model for drug permeability studies. Fluids Barriers CNS 2013, 10: 33.

Cited by 32 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Unraveling neurovascular mysteries: the role of endothelial glycocalyx dysfunction in Alzheimer’s disease pathogenesis;Frontiers in Physiology;2024-07-04

2. Co-Culture Models: Key Players in In Vitro Neurotoxicity, Neurodegeneration and BBB Modeling Studies;Biomedicines;2024-03-12

3. Human in vitro blood barrier models: architectures and applications;Tissue Barriers;2023-06-20

4. Experimental Models of In Vitro Blood–Brain Barrier for CNS Drug Delivery: An Evolutionary Perspective;International Journal of Molecular Sciences;2023-01-31

5. Challenges and opportunities in the use of transcriptomic characterization of human iPSC-derived BBB models;Toxicology in Vitro;2022-10