Cytochrome P450 dependent xenobiotic activation by physiological hydroperoxides in intact hepatocytes
Author:
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology (medical),Pharmacology
Link
http://link.springer.com/content/pdf/10.1007/BF03190961.pdf
Reference23 articles.
1. Anari M.R., Khan S., Liu Z.C., O’Brien P.J. (1995): Cytochrome P450 peroxidase/peroxygenase mediated xenobiotic metabolic activation and cytotoxicity in isolated hepatocytes. Chem. Res. Toxicol., 8, 997–1004.
2. Anari M.R., Josephy P.D., Henrey T., O’Brien P.J. (1997): Hydrogen peroxide supports human and rat cytochrome P450 1A2-catalyzed 2-amino-3-methyl imidazo [4,5-f] quinoline bioactivation to mutagenic metabolites: significance of cytochrome P450 peroxygenase. Chem. Res. Toxicol., 10, 528–534.
3. O’Brien P.J. (1978): Hydroperoxides and superoxides in microsomal oxidations. Pharmacol. Ther., A2, 517–537.
4. Hycay E.G., O’Brien P.J. (1971): Cytochrome P450 as a microsomal peroxidase utilizing a lipid peroxide substrate. Arch. Biochem. Biophys., 147, 14–27.
5. Estabrook R.W., Martin-Wixtrom C., Saeki Y., Renneberg R., Hildebrandt A., Werringloer J. (1994): The peroxidatic function of liver microsomal cytochrome P450: comparison of hydrogen peroxide and NADPH catalysed N-demethylation reactions. Xenobiotica, 14, 87–104.
Cited by 22 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Use of engineered cytochromes P450 for accelerating drug discovery and development;Pharmacology and Toxicology of Cytochrome P450 – 60th Anniversary;2022
2. Fatty Acid Hydroperoxides Support Cytochrome P450 2S1-Mediated Bioactivation of Benzo[a]pyrene-7,8-dihydrodiol;Molecular Pharmacology;2009-08-27
3. Functional Characterization of Human Cytochrome P450 2S1 Using a Synthetic Gene-Expressed Protein inEscherichia coli;Molecular Pharmacology;2009-08-27
4. Role of hydrazine in isoniazid-induced hepatotoxicity in a hepatocyte inflammation model;Toxicology and Applied Pharmacology;2008-05
5. Accelerated Cytotoxic Mechanism Screening of Hydralazine Using an in Vitro Hepatocyte Inflammatory Cell Peroxidase Model;Chemical Research in Toxicology;2008-04-01
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3