Timing of Subsequent Fractures after an Initial Fracture

Author:

van Geel Tineke A. C. M.,Huntjens Kirsten M. B.,van den Bergh Joop P. W.,Dinant Geert-Jan,Geusens Piet P.

Publisher

Springer Science and Business Media LLC

Subject

Endocrinology, Diabetes and Metabolism

Reference17 articles.

1. World Health Organization: W.H.O. Prevention and Management of Osteoporosis. Report of a WHO Scientific Group. WHO Technical Report Series 2003; No 921. Geneva, Switzerland: World Health Organization; 2003.

2. World Health Organization: WHO Scientific Group on the assessment of osteoporosis at primary health care level. Summary Meeting Report, Brussels, Belgium, 5–7 May 2004. Available at www.who.int/chp/topics/Osteoporosis.pdf . Accessed May 2010.

3. Klotzbuecher CM, Ross PD, Landsman PB, et al.: Patients with prior fractures have an increased risk of future fractures: a summary of the literature and statistical synthesis. J Bone Miner Res 2000, 15:721–727.

4. •• Center JR, Bliuc D, Nguyen TV, Eisman JA: Risk of subsequent fracture after low-trauma fracture in men and women. JAMA 2007, 297:387–394. This study examined the subsequent risk of all fracture types, except fingers and toes, after an initial low-energy trauma fracture in men and women 60 years of age and over taking into account the time relation between fractures. The risk of subsequent fracture was highest immediately after the initial fracture, but was not higher than the risk for individuals without a fracture 10 years after the initial fracture (41% of the subsequent fractures occurred within 2 years).

5. •• van Geel TA, van Helden S, Geusens PP, et al.: Clinical subsequent fractures cluster in time after first fractures. Ann Rheum Dis 2009, 68:99–102. The results of this study extend the observations of Center et al. [4••] to all clinical vertebral and nonvertebral fractures, in women from menopause onward, and for both low- and high-energy trauma fractures. The initial fracture type was not a predictor for subsequent fractures. The subsequent fracture risk remained higher, compared with initial fracture risk, for 15 years after the initial fracture (23% of the subsequent fractures occurred within 1 year).

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