Author:
Cui Zishan,Karamouzian Mohammad,Law Michael,Hayashi Kanna,Milloy M-J,Kerr Thomas
Abstract
AbstractPolysubstance use is prevalent among individuals on opioid agonist treatment (OAT), yet past studies have focused primarily on distinct substances and their association with OAT retention. Data was collected from two prospective cohorts between 2005 and 2020 in Vancouver, Canada. Among 13,596 visits contributed by 1445 participants receiving OAT, we employed repeated measures latent class analysis using seven indicators and identified four longitudinal substance use classes. Using marginal structural Cox modeling, we found that compared to the primarily crack use class, the two opioid and stimulant use classes carried a higher risk of OAT discontinuation, while the primarily cannabis and crack use class had a lower OAT discontinuation risk. Our findings highlight the need for integrated treatment strategies to manage the co-use of opioids and stimulants during receipt of OAT and suggest future research should explore the potential of cannabis as a harm reduction strategy or adjunctive treatment to OAT.Word count: 150/150.
Funder
Canadian Institutes of Health Research
National Institutes of Health
Michael Smith Health Research BC
St. Paul’s Foundation
Publisher
Springer Science and Business Media LLC
Subject
Psychiatry and Mental health
Reference76 articles.
1. Amiri, S., Hirchak, K., Lutz, R., McDonell, M. G., McPherson, S. M., Roll, J. M., & Amram, O. (2018). Three-year retention in methadone opioid agonist treatment: A survival analysis of clients by dose, area deprivation, and availability of alcohol and cannabis outlets. Drug and Alcohol Dependence, 193, 63–68. https://doi.org/10.1016/j.drugalcdep.2018.08.024.
2. Bahji, A., Cheng, B., Gray, S., & Stuart, H. (2019). Reduction in mortality risk with opioid agonist therapy: A systematic review and meta-analysis. Acta Psychiatrica Scandinavica. https://doi.org/10.1111/acps.13088.
3. Banks, D. E., Hershberger, A. R., Pemberton, T., Clifton, R. L., Aalsma, M. C., & Zapolski, T. C. B. (2019). Poly-use of cannabis and other substances among juvenile-justice involved youth: Variations in psychological and substance-related problems by typology. American Journal of Drug and Alcohol Abuse, 45(3), 313–322. https://doi.org/10.1080/00952990.2018.1558450.
4. Banta-Green, C. J., Maynard, C., Koepsell, T. D., Wells, E. A., & Donovan, D. M. (2009). Retention in methadone maintenance drug treatment for prescription-type opioid primary users compared to heroin users. Addiction, 104(5), 775–783. https://doi.org/10.1111/j.1360-0443.2009.02538.x.
5. BC Coroners Service (2020). Fentanyl-Detected Illicit Drug Toxicity Deaths. http://www2.gov.bc.ca/gov/content/safety/public-safety/death-investigation/statistical. Accessed 3 June 2021.
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献