The first evidence of biological activity for free Hypusine, an enigmatic amino acid discovered in the '70s
Author:
Funder
Fundação de Amparo à Pesquisa do Estado de São Paulo
Publisher
Springer Science and Business Media LLC
Subject
Organic Chemistry,Clinical Biochemistry,Biochemistry
Link
https://link.springer.com/content/pdf/10.1007/s00726-023-03283-4.pdf
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2. Barba-Aliaga M, Alepuz P (2022) Role of eIF5A in mitochondrial function. Int J Mol Sci 23(3):1284. https://doi.org/10.3390/ijms23031284
3. Baskal S, Kaiser A, Mels C, Kruger R, Tsikas D (2022) Specific and sensitive GC–MS analysis of hypusine, Nε-(4-amino-2-hydroxybutyl)lysine, a biomarker of hypusinated eukaryotic initiation factor eIF5A, and its application to the bi-ethnic ASOS study. Amino Acids 54(7):1083–1099. https://doi.org/10.1007/s00726-022-03142-8
4. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248–254. https://doi.org/10.1006/abio.1976.9999
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1. The Many Faces of Hypusinated eIF5A: Cell Context-Specific Effects of the Hypusine Circuit and Implications for Human Health;International Journal of Molecular Sciences;2024-07-26
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