The biological interactions between kynurenine and AhR in melanocytes: in vitro studies-Reference-Cited by-同舟云学术

The biological interactions between kynurenine and AhR in melanocytes: in vitro studies

Published:2023-05-28 Issue:7 Volume:55 Page:947-954
ISSN:0939-4451
Container-title:Amino Acids
language:en
Short-container-title:Amino Acids

Author:

Walczak Katarzyna^ORCID,Szalast Karolina^ORCID,Krasowska Dorota^ORCID

Abstract

AbstractKynurenine (KYN), a tryptophan metabolite, is endogenously produced by the skin cells and is present in human sweat. The aim of this study was to determine the molecular mechanism of the antiproliferative activity of KYN on human epidermal melanocytes. KYN significantly inhibited the metabolic activity of HEMa cells by decreasing cyclin D1 and cyclin-dependent kinase 4 (CDK4) levels via the aryl hydrocarbon receptor (AhR) pathway. The results suggested that KYN might be involved in the regulation of physiological and pathological processes mediated by melanocytes.

Funder

Medical University of Lublin

Publisher

Springer Science and Business Media LLC

Subject

Organic Chemistry,Clinical Biochemistry,Biochemistry

Link

https://link.springer.com/content/pdf/10.1007/s00726-023-03279-0.pdf

Reference33 articles.

1. Berridge MV, Herst PM, Tan AS (2005) Tetrazolium dyes as tools in cell biology: new insights into their cellular reduction. Biotechnol Annu Rev 11:127–152. https://doi.org/10.1016/s1387-2656(05)11004-7

2. Cervenka I, Agudelo LZ, Ruas JL (2017) Kynurenines: Tryptophan’s metabolites in exercise, inflammation, and mental health. Science 357(6349):eaaf9794. https://doi.org/10.1126/science.aaf9794

3. Che X, Dai W (2019) Negative regulation of aryl hydrocarbon receptor by its lysine mutations and exposure to nickel. Mol Cell Toxicol 15(4):459–467. https://doi.org/10.1007/s13273-019-0050-8

4. DiNatale BC, Murray IA, Schroeder JC, Flaveny CA, Lahoti TS, Laurenzana EM, Omiecinski CJ, Perdew GH (2010) Kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of inflammatory signaling. Toxicol Sci 115(1):89–97. https://doi.org/10.1093/toxsci/kfq024

5. Fernández-Gallego N, Sánchez-Madrid F, Cibrian D (2021) Role of AHR ligands in skin homeostasis and cutaneous inflammation. Cells 10(11):3176. https://doi.org/10.3390/cells10113176