Abstract
AbstractImpurities in nine dietary supplements containing l-tryptophan were evaluated using an HPLC methodology. In five tested products, the total impurities were higher than the thresholds described in the Food Chemical Codex or implemented in the EU for pharmaceutical grade l-tryptophan. In addition, liquid chromatography–mass spectrometry was used to specifically test for the presence of 1,1′-ethylidenebis-l-tryptophan (EBT). None of the tested products contained detectable amounts of EBT. High amounts of unidentified impurities in some dietary supplements point to potential health risks.
Publisher
Springer Science and Business Media LLC
Subject
Organic Chemistry,Clinical Biochemistry,Biochemistry
Reference16 articles.
1. Allen JA, Peterson A, Sufit R et al (2011) Post-epidemic eosinophilia-myalgia syndrome associated with l-tryptophan. Arthritis Rheum 63:3633–3639
2. Al-Mokbel A, Courtney-Martin G, Elango R et al (2019) Tryptophan requirement in school-age children determined by the indicator amino acid oxidation method is similar to current recommendations. J Nutr 149:280–285
3. Deutz NE, Simbo SY, Ligthart-Melis GC et al (2017) Tolerance to increased supplemented dietary intakes of methionine in healthy older adults. Am J Clin Nutr 106:675–683
4. DRI (Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino acids) (2005) The National Academic Press, USA https://www.nap.edu/catalog/10490/dietary-reference-intakes-for-energy-carbohydrate-fiber-fat-fatty-acids-cholesterol-protein-and-amino-acids. Accessed 16 Nov 2021
5. Fernstrom JD (2012) Effects and side effects associated with the non-nutritional use of tryptophan by humans. J Nutr 142:2236S-2244S
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