Divergent synthesis of biologically active l-threo-β-hydroxyaspartates from common trans-oxazolidine dicarboxylate
Author:
Publisher
Springer Science and Business Media LLC
Subject
Organic Chemistry,Clinical Biochemistry,Biochemistry
Link
https://link.springer.com/content/pdf/10.1007/s00726-022-03196-8.pdf
Reference37 articles.
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3. Cardillo G, Gentilucci L, Tolomelli A, Tomasini C (1999) A practical method for the synthesis of β-amino α-hydroxy acids. Synthesis of enantiomerically pure hydroxyaspartic acid and isoserine. Synlett. https://doi.org/10.1055/s-1999-2927
4. De Villiers J, De Villiers M, Geertsema EM et al (2015) Chemoenzymatic synthesis of ortho-, meta-, and para-substituted derivatives of l-threo-3-benzyloxyaspartate, an important glutamate transporter blocker. ChemCatChem 7:1931–1934. https://doi.org/10.1002/cctc.201500318
5. Fernández-Megía E, Paz MM, Sardina FJ (1994) On the stereoselectivity of the reaction of N-(9-Phenylfluoren-9-yl)aspartate Enolates with electrophiles. Synthesis of enantiomerically pure 3-hydroxy-, 3-amino-, and 3-hydroxy-3-methylaspartates. J Org Chem 59:7643–7652. https://doi.org/10.1021/jo00104a019
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2. Discussion Addendum for: Synthesis of N-Boc-N-Hydroxymethyl-L-phenylalaninal and Methyl trans-Oxazolidine-5-carboxylate, Chiral Synthons for threo-b-Amino-a-hydroxy Acids;ORG SYNTH;2022
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