Pharmacokinetics of chlorpromazine and key metabolites

Author:

Yeung P. K. -F.,Hubbard J. W.,Korchinski E. D.,Midha K. K.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology,General Medicine

Reference27 articles.

1. Turano P, Turner WJ, Manian AA (1973) Thin-layer chromatography of chlorpromazine metabolites. Attempt to identify each of the metabolites appearing in the blood, urine and feces of chronically medicated schizophrenics. J Chromatogr 75: 277?293

2. Kleinmann JE, Bigelow LB, Rogol A, Weinberger DR, Nasrallah HA, Wyatt RJ, Gillin JC (1980) A clinical trial of 7-hydroxy-chlorpromazine in chronic schizophrenia. In: Usdin E, Eckert H, Forrest IS (ed) Phenothiazines and structurally related drugs: Basic and clinical studies, Elsevier, Amsterdam New York Oxford, pp 275?278

3. Nyback H, Sedvall G (1972) Effect of chlorpromazine and some of its metabolites on synthesis and turnover of catecholamines formed from 14C-tyrosine in mouse brain. Psychopharmacologia (Berl) 26: 155?160

4. Dahl SG (1982) Active metabolites of neuroleptic drugs: Possible contribution to therapeutic and toxic effects. Ther Drug Monit 4: 33?40

5. Dahl SG, Hjorth M, Hough E (1982) Chlorpromazine, methotrimeprazine and metabolites. Structural changes accompanying the loss of neuroleptic potency by ring sulforxidation. Mol Pharmacol 21: 409?414

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