Preclinical evidence of sphingosine kinase 1 inhibition in alleviation of intestinal epithelial injury in polymicrobial sepsis
Author:
Funder
Health and Medical Research Fund, Food and Health Bureau, Hong Kong
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology,Immunology
Link
http://link.springer.com/content/pdf/10.1007/s00011-019-01255-7.pdf
Reference10 articles.
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2. Doig CJ, Sutherland LR, Sandham JD, Fick GH, Verhoef M, Meddings JB. Increased intestinal permeability is associated with the development of multiple organ dysfunction syndrome in critically ill ICU patients. Am J Respir Crit Care Med. 1998;158(2):444–51.
3. Assimakopoulos SF, Triantos C, Thomopoulos K, Fligou F, Maroulis I, Marangos M, et al. Gut-origin sepsis in the critically ill patient: pathophysiology and treatment. Infection. 2018;46:751–60.
4. Snider AJ, Kawamori T, Bradshaw SG, Orr KA, Gilkeson GS, Hannun YA, et al. A role for sphingosine kinase 1 in dextran sulphate sodium-induced colitis. The FASEB J. 2009;23(1):143–52.
5. Itagaki K, Zhang Q, Hauser CJ. Sphingosine kinase inhibition alleviates endothelial permeability induced by thrombin and activated neutrophils. Shock. 2010;33(4):381–6.
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