Transcriptomic analysis of hidradenitis suppurativa skin suggests roles for multiple inflammatory pathways in disease pathogenesis
Author:
Funder
Incyte Research Institute
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology,Immunology
Link
https://link.springer.com/content/pdf/10.1007/s00011-020-01381-7.pdf
Reference10 articles.
1. Sabat R, Jemec GBE, Matusiak L, Kimball AB, Prens E, Wolk K. Hidradenitis suppurativa. Nat Rev Dis Primers. 2020;6:18.
2. Hessam S, Sand M, Gambichler T, et al. Correlation of inflammatory serum markers with disease severity in subjects with hidradenitis suppurativa (HS). J Am Acad Dermatol. 2015;73:998–1005.
3. Matusiak L, Szczech J, Bieniek A, et al. Increased interleukin (IL)-17 serum levels in subjects with hidradenitis suppurativa: implications for treatment with anti-IL-17 agents. J Am Acad Dermatol. 2017;76:670–5.
4. Kimball AB, Okun MM, Williams DA, et al. Two phase 3 trials of adalimumab for hidradenitis suppurativa. N Engl J Med. 2016;375:422–34.
5. Scheinfeld N, Sundaram M, Teixeira H, et al. Reduction in pain scores and improvement in depressive symptoms in subjects with hidradenitis suppurativa treated with adalimumab in a phase 2, randomized, placebo-controlled trial. Dermatol Online J. 2016;22(3):2.
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2. Brepocitinib, Zimlovisertib, and Ropsacitinib in Hidradenitis Suppurativa;NEJM Evidence;2024-02-27
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5. Transcriptomic Analysis of Hidradenitis Suppurativa: A Unique Molecular Signature with Broad Immune Activation;International Journal of Molecular Sciences;2023-11-30
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