T-helper cell intrinsic defects in lupus that break peripheral tolerance to nuclear autoantigens

Author:

Datta Syamal K.,Zhang Li,Xu Luting

Publisher

Springer Science and Business Media LLC

Subject

Genetics (clinical),Drug Discovery,Molecular Medicine

Reference183 articles.

1. Boumpas DT, Austin HA, Fessler BJ, Balow JE, Klippel JH, Lockshin MD (1995) Systemic lupus erythematosus: emerging concepts. I. Renal, neuropschyatric, cardiovascular, pulmonary and hematologic disease. Ann Intern Med 122:940?950

2. Datta SK, Patel H, Berry D (1987) Induction of a cationic shift in IgG anti-DNA autoantibodies. Role of T helper cells with classical and novel phenotypes in three murine models of lupus nephritis. J Exp Med 165:1252?1268

3. Shivakumar S, Tsokos GC, Datta SK (1989) T cell receptor alpha/beta expressing double negative (CD4-/CD8-) and CD4+ T helper cells in humans augment the production of pathogenic anti-DNA autoantibodies associated with lupus nephritis. J Immunol 143:103?112

4. Naiki M, Chiang B-L, Cawley D, Ansari A, Rozzo SJ, Kotzin BL, Zlotnik A, Gershwin ME (1992) Generation and characterization of cloned helper T cell lines for anti-DNA responses in NZB.H-2bm12 mice. J Immunol 149:4109?4115

5. Singh RR, Kumar V, Ebling FM, Southwood S, Sette A, Sercarz EE, Hahn BH (1995) T cell determinants from autoantibodies to DNA can upregulate autoimmunity in murine SLE. J Exp Med 181:2017?2027

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