The CCHCR1 (HCR) gene is relevant for skin steroidogenesis and downregulated in cultured psoriatic keratinocytes-Reference-Cited by-同舟云学术

The CCHCR1 (HCR) gene is relevant for skin steroidogenesis and downregulated in cultured psoriatic keratinocytes

Published:2007-01-13 Issue:6 Volume:85 Page:589-601
ISSN:0946-2716
Container-title:Journal of Molecular Medicine
language:en
Short-container-title:J Mol Med

Author:

Tiala Inkeri,Suomela Sari,Huuhtanen Jari,Wakkinen Janica,Hölttä-Vuori Maarit,Kainu Kati,Ranta Sirpa,Turpeinen Ursula,Hämäläinen Esa,Jiao Hong,Karvonen Seija-Liisa,Ikonen Elina,Kere Juha,Saarialho-Kere Ulpu,Elomaa Outi

Publisher

Springer Science and Business Media LLC

Subject

Genetics (clinical),Drug Discovery,Molecular Medicine

Link

http://link.springer.com/content/pdf/10.1007/s00109-006-0155-0.pdf

Reference46 articles.

1. Asumalahti K, Laitinen T, Itkonen-Vatjus R, Lokki ML, Suomela S, Snellman E, Saarialho-Kere U, Kere J (2000) A candidate gene for psoriasis near HLA-C, HCR (Pg8), is highly polymorphic with a disease-associated susceptibility allele. Hum Mol Genet 9:1533–1542

2. Asumalahti K, Veal C, Laitinen T, Suomela S, Allen M, Elomaa O, Moser M, de Cid R, Ripatti S, Vorechovsky I, Marcusson J, Nakagawa H, Lazaro X, Capon F, Novelli G, The Psoriasis Consortium, Saarialho-Kere U, Barker J, Thrembath R, Kere J (2002) Coding haplotype analysis supports HCR as the putative susceptibility gene for psoriasis at the MHC PSORS1 locus. Hum Mol Genet 11:589–597

3. Bowcock AM, Cookson WO (2004) The genetics of psoriasis, psoriatic arthritis and atopic dermatitis. Hum Mol Genet 13(Spec No 1):R43–R55

4. Suomela S, Elomaa O, Asumalahti K, Kariniemi AL, Karvonen SL, Peltonen J, Kere J, Saarialho-Kere U (2003) HCR, a candidate gene for psoriasis, is expressed differently in psoriasis and other hyperproliferative skin disorders and is downregulated by interferon-gamma in keratinocytes. J Invest Dermatol 121:1360–1364

5. Elomaa O, Majuri I, Suomela S, Asumalahti K, Jiao H, Mirzaei Z, Rozell B, Dahlman-Wright K, Pispa J, Kere J, Saarialho-Kere U (2004) Transgenic mouse models support HCR as an effector gene in the PSORS1 locus. Hum Mol Genet 13:1551–1561

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