Identification and preclinical development of an anti-proteolytic uPA antibody for rheumatoid arthritis
Author:
Publisher
Springer Science and Business Media LLC
Subject
Genetics(clinical),Drug Discovery,Molecular Medicine
Link
http://link.springer.com/content/pdf/10.1007/s00109-020-01889-9.pdf
Reference22 articles.
1. Chaudhari K, Rizvi S, Syed BA (2016) Rheumatoid arthritis: current and future trends. Nat Rev Drug Discov 15:305–306
2. Kłak A, Paradowska-Gorycka A, Kwiatkowska B, Raciborski F (2016) Personalized medicine in rheumatology. Reumatologia 54:177–186
3. Almholt K, Hebsgaard JB, Nansen A, Andersson C, Pass J, Rønø B, Thygesen P, Pelzer H, Loftager M, Lund IK et al (2018) Antibody-mediated neutralization of uPA proteolytic function reduces disease progression in mouse arthritis models. J Immunol 200:957–965
4. Buckley BJ, Ali U, Kelso MJ, Ranson M (2019) The urokinase plasminogen activation system in rheumatoid arthritis: pathophysiological roles and prospective therapeutic targets. Curr Drug Targets 20:970–981
5. Cook AD, Braine EL, Campbell IK, Hamilton JA (2002) Differing roles for urokinase and tissue-type plasminogen activator in collagen-induced arthritis. Am J Pathol 160:917–926
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