Hyperinsulinemia reduces osteoblast activity in vitro via upregulation of TGF-β-Reference-Cited by-同舟云学术

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Hyperinsulinemia reduces osteoblast activity in vitro via upregulation of TGF-β

Published:2012-08-29 Issue:11 Volume:90 Page:1257-1266
ISSN:0946-2716
Container-title:Journal of Molecular Medicine
language:en
Short-container-title:J Mol Med

Author:

Freude Thomas,Braun Karl Friedrich,Haug Alexander,Pscherer Stefan,Stöckle Ulrich,Nussler Andreas Klaus,Ehnert Sabrina

Publisher

Springer Science and Business Media LLC

Subject

Genetics (clinical),Drug Discovery,Molecular Medicine

Link

http://link.springer.com/content/pdf/10.1007/s00109-012-0948-2.pdf

Reference28 articles.

1. Retzepi M, Donos N (2010) The effect of diabetes mellitus on osseous healing. Clin Oral Implants Res 21:673–681

2. Vestergaard P (2007) Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes—a meta-analysis. Osteoporos Int 18:427–444

3. Kimura S, Sasase T, Ohta T, Sato E, Matsushita M (2011) Characteristics of bone turnover, bone mass and bone strength in Spontaneously Diabetic Torii-Lepr (fa) rats. J Bone Miner Metab 30:312–320

4. Takizawa M, Suzuki K, Matsubayashi T, Kikuyama M, Suzuki H, Takahashi K, Katsuta H, Mitsuhashi J, Nishida S, Yamaguchi S et al (2008) Increased bone resorption may play a crucial role in the occurrence of osteopenia in patients with type 2 diabetes: possible involvement of accelerated polyol pathway in its pathogenesis. Diabetes Res Clin Pract 82:119–126

5. Sayers A, Lawlor D, Sattar N, Tobias J (2011) The association between insulin levels and cortical bone: findings from a cross sectional analysis of pQCT parameters in adolescents. J Bone Miner Res 27:610–618

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