Affiliation:
1. Department of Cell Biology and Histology, Faculty of Medicine, Bucharest 35, PO Box 35-10, Romania
Abstract
The sarcolemma of smooth-muscle ceils from human pregnant myometrium possesses a high-affinity Ca2+-ATPase, which has the characteristics of an active Ca2+-extrusion pump. This pump enzyme, either membrane-bound or solubilized, was strongly inhibited by oxytocin (half-maximal inhibition at about 4 μU/ml or 10 pM). However, under similar conditions, oxytocin did not inhibit Ca2+extrusion ATPase of the erythrocyte membrane. The inhibitory concentrations of oxytocin correspond to hormone plasma levels which initiate spontaneous labor.
Subject
Cell Biology,Molecular Biology,Biochemistry,Biophysics
Reference21 articles.
1. Akerman KEO & Wikström MKF (1979) (Ca2++Mg2+)-stimulated ATPase activity of rabbit myometrium plasma membrane is blocked by oxytocin. FEBS Lett.97, 283?287.
2. Berde B & Boissonas RA (1968) Basic pharmacological properties of synthetic analogues and homologues of the neurohypophysial hormones. In: Handbook of Experimental Pharmacology (Berde B, ed), vol 23, pp 802?870, Springer Verlag, Berlin.
3. Carafoli E & Zurini M (1982) The Ca2+-pumping ATPase of plasma membranes. Biochim. Biophys. Acta683, 279?301.
4. Carafoli E, Inesi G & Rosen BP (1984) Calcium transport across biological membranes. In: Calcium and Its Role in Biology (Siegel A, ed), pp 129?186, Marcel Dekker, New York.
5. Crankshaw DJ, Branda LA, Matlib MA & Daniel EE (1978) Localization of the oxytocin receptor in the plasma membrane of rat myometrium. Eur. J. Biochem.86, 481?486.
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