Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile-Reference-Cited by-同舟云学术

Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile

Published:2016-04-02 Issue:1 Volume:91 Page:439-452
ISSN:0340-5761
Container-title:Archives of Toxicology
language:en
Short-container-title:Arch Toxicol

Author:

Heslop James A.,Rowe Cliff,Walsh Joanne,Sison-Young Rowena,Jenkins Roz,Kamalian Laleh,Kia Richard,Hay David,Jones Robert P.,Malik Hassan Z.,Fenwick Stephen,Chadwick Amy E.,Mills John,Kitteringham Neil R.,Goldring Chris E. P.,Kevin Park B.

Funder

Biotechnology and Biological Sciences Research Council (GB)

Medical Research Council (GB)

European Parliament (BE)

Publisher

Springer Science and Business Media LLC

Subject

Health, Toxicology and Mutagenesis,Toxicology,General Medicine

Link

http://link.springer.com/content/pdf/10.1007/s00204-016-1694-y.pdf

Reference44 articles.

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2. Bhogal RH, Hodson J, Bartlett DC et al (2011) Isolation of primary human hepatocytes from normal and diseased liver tissue: a one hundred liver experience. PLoS ONE 6(3):e18222. doi: 10.1371/journal.pone.0018222

3. Darnell M, Ulvestad M, Ellis E, Weidolf L, Andersson TB (2012) In vitro evaluation of major in vivo drug metabolic pathways using primary human hepatocytes and HepaRG cells in suspension and a dynamic three-dimensional bioreactor system. J Pharmacol Exp Ther 343(1):134–144

4. Elaut G, Henkens T, Papeleu P et al (2006) Molecular mechanisms underlying the dedifferentiation process of isolated hepatocytes and their cultures. Curr Drug Metab 7(6):629–660

5. Fraczek JE, Vinken M, Tourwe D, Vanhaecke T, Rogiers V (2012) Synergetic effects of DNA demethylation and histone deacetylase inhibition in primary rat hepatocytes. Invest New Drugs 30(4):1715–1724. doi: 10.1007/s10637-011-9659-8

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