Hazard characterization of Alternaria toxins to identify data gaps and improve risk assessment for human health
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Published:2023-12-26
Issue:2
Volume:98
Page:425-469
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ISSN:0340-5761
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Container-title:Archives of Toxicology
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language:en
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Short-container-title:Arch Toxicol
Author:
Louro HenriquetaORCID, Vettorazzi ArianeORCID, López de Cerain AdelaORCID, Spyropoulou AnastasiaORCID, Solhaug AnitaORCID, Straumfors AnneORCID, Behr Anne-CathrinORCID, Mertens BirgitORCID, Žegura BojanaORCID, Fæste Christiane KruseORCID, Ndiaye DieynabaORCID, Spilioti ElianaORCID, Varga ElisabethORCID, Dubreil EstelleORCID, Borsos EszterORCID, Crudo FrancescoORCID, Eriksen Gunnar SundstølORCID, Snapkow IgorORCID, Henri JérômeORCID, Sanders JulieORCID, Machera KyriakiORCID, Gaté LaurentORCID, Le Hegarat LudovicORCID, Novak MatjažORCID, Smith Nicola M.ORCID, Krapf SolveigORCID, Hager SonjaORCID, Fessard ValérieORCID, Kohl YvonneORCID, Silva Maria JoãoORCID, Dirven HubertORCID, Dietrich JessicaORCID, Marko DorisORCID
Abstract
AbstractFungi of the genus Alternaria are ubiquitous plant pathogens and saprophytes which are able to grow under varying temperature and moisture conditions as well as on a large range of substrates. A spectrum of structurally diverse secondary metabolites with toxic potential has been identified, but occurrence and relative proportion of the different metabolites in complex mixtures depend on strain, substrate, and growth conditions. This review compiles the available knowledge on hazard identification and characterization of Alternaria toxins. Alternariol (AOH), its monomethylether AME and the perylene quinones altertoxin I (ATX-I), ATX-II, ATX-III, alterperylenol (ALP), and stemphyltoxin III (STTX-III) showed in vitro genotoxic and mutagenic properties. Of all identified Alternaria toxins, the epoxide-bearing analogs ATX-II, ATX-III, and STTX-III show the highest cytotoxic, genotoxic, and mutagenic potential in vitro. Under hormone-sensitive conditions, AOH and AME act as moderate xenoestrogens, but in silico modeling predicts further Alternaria toxins as potential estrogenic factors. Recent studies indicate also an immunosuppressive role of AOH and ATX-II; however, no data are available for the majority of Alternaria toxins. Overall, hazard characterization of Alternaria toxins focused, so far, primarily on the commercially available dibenzo-α-pyrones AOH and AME and tenuazonic acid (TeA). Limited data sets are available for altersetin (ALS), altenuene (ALT), and tentoxin (TEN). The occurrence and toxicological relevance of perylene quinone-based Alternaria toxins still remain to be fully elucidated. We identified data gaps on hazard identification and characterization crucial to improve risk assessment of Alternaria mycotoxins for consumers and occupationally exposed workers.
Funder
European Commission University of Vienna
Publisher
Springer Science and Business Media LLC
Subject
Health, Toxicology and Mutagenesis,Toxicology,General Medicine
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