Accuracy, discriminative properties and reliability of a human ESC-based in vitro toxicity assay to distinguish teratogens responsible for neural tube defects
Author:
Funder
Swiss Centre for Applied Human Toxicology
Publisher
Springer Science and Business Media LLC
Subject
Health, Toxicology and Mutagenesis,Toxicology,General Medicine
Link
http://link.springer.com/content/pdf/10.1007/s00204-019-02512-8.pdf
Reference37 articles.
1. Balmer NV, Weng MK, Zimmer B et al (2012) Epigenetic changes and disturbed neural development in a human embryonic stem cell-based model relating to the fetal valproate syndrome. Hum Mol Genet 21(18):4104–4114
2. Bal-Price A, Pistollato F, Sachana M, Bopp SK, Munn S, Worth A (2018) Strategies to improve the regulatory assessment of developmental neurotoxicity (DNT) using in vitro methods. Toxicol Appl Pharmacol 15:15. https://doi.org/10.1016/j.taap.2018.02.008
3. Baumann J, Gassmann K, Masjosthusmann S et al (2016) Comparative human and rat neurospheres reveal species differences in chemical effects on neurodevelopmental key events. Arch Toxicol 90(6):1415–1427
4. Cahan P, Daley GQ (2013) Origins and implications of pluripotent stem cell variability and heterogeneity. Nat Rev Mol Cell Biol 14(6):357–368
5. Colleoni S, Galli C, Gaspar JA et al (2011) Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci 124(2):370–377
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2. An efficient neuron-astrocyte differentiation protocol from human embryonic stem cell-derived neural progenitors to assess chemical-induced developmental neurotoxicity;Reproductive Toxicology;2020-12
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