Characterization of the toxicity, mutagenicity, and carcinogenicity of methacrylonitrile in F344 Rats and B6C3F1 mice

Author:

Nyska Abraham,Ghanayem Burhan I.

Publisher

Springer Science and Business Media LLC

Subject

Health, Toxicology and Mutagenesis,Toxicology,General Medicine

Reference46 articles.

1. ATSDR (Agency for Toxic Substances and Disease Registry) (1990) Toxicological Profile for Acrylonitrile. US Department of Health and Human Services, Public Health Service, National Institutes of Health, Research Triangle Park, NC

2. Ahmed AE, Jacob S, Ghanayem BI (1996) Comparative disposition of acrylonitrile and methacrylonitrile: quantitative whole body autoradiographic studies in rats. Fundam Appl Toxicol 33:49–59

3. Bailer AJ, Portier CJ (1988) Effects of treatment-induced mortality and tumor-induced mortality on tests for carcinogenicity in small samples. Biometrics 44:417–431

4. Benz FW, Nerland DE, Pierce WM, Babiuk C (1990) Acute acrylonitrile toxicity studies on the mechanism of the antidotal effect of d-cysteine and l-cysteine and their N-acetyl derivatives in the rat. Toxicol Appl Pharmacol 102:142–150

5. BioDynamics, Inc. (1980) A twenty-four month oral toxicity/carcinogenicity study of acrylonitrile administered by intubation to spartan rats. Final report. Two volumes. Division of Biology and Safety Evaluation. Submitted by Monsanto Company, St. Louis, MO (Project No. 77-1746; Bdn 77-29)

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