Metabolism of acrylamide to glycidamide and their cytotoxicity in isolated rat hepatocytes: protective effects of GSH precursors
Author:
Publisher
Springer Science and Business Media LLC
Subject
Health, Toxicology and Mutagenesis,Toxicology,General Medicine
Link
http://link.springer.com/content/pdf/10.1007/s00204-006-0109-x.pdf
Reference30 articles.
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2. Calleman CJ, Bergmark E, Costa LG (1990) Acrylamide is metabolized to glycidamide in the rat: evidence from hemoglobin adduct formation. Chem Res Toxicol 3:406–412
3. Castell JV, Gomez-Lechon MJ, Ponsoda X, Bort R (1997) In vitro investigation of the molecular mechanisms of hepatotoxicity. Arch Toxicol Suppl 19:313–321
4. Dearfield KL, Abernathy CO, Ottley MS, Brantner JH, Haynes PF (1988) Acrylamide: its metabolism, developmental and reproductive effects, genotoxicity, and carcinogenicity. Mutat Res 195:45–77
5. Dixit R, Mukhtar H, Seth P, Murti CR (1981) Conjugation of acrylamide with glutathione catalyzed by glutathione-S-transferases of rat liver and brain. Biochem Pharmacol 30:1739–1744
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