Long-term exposure of immortalized keratinocytes to arsenic induces EMT, impairs differentiation in organotypic skin models and mimics aspects of human skin derangements-Reference-Cited by-同舟云学术

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Long-term exposure of immortalized keratinocytes to arsenic induces EMT, impairs differentiation in organotypic skin models and mimics aspects of human skin derangements

Published:2017-08-03 Issue:1 Volume:92 Page:181-194
ISSN:0340-5761
Container-title:Archives of Toxicology
language:en
Short-container-title:Arch Toxicol

Author:

Weinmuellner R.,Kryeziu K.,Zbiral B.,Tav K.,Schoenhacker-Alte B.,Groza D.,Wimmer L.,Schosserer M.,Nagelreiter F.,Rösinger S.,Mildner M.,Tschachler E.,Grusch M.,Grillari J.,Heffeter P.^ORCID

Funder

Austrian Science Fund

Austrian Federal Ministry of Science, Research and Economy

National Foundation for Research, Technology and Development

Christian Doppler Forschungsgesellschaft

Publisher

Springer Science and Business Media LLC

Subject

Health, Toxicology and Mutagenesis,Toxicology,General Medicine

Link

http://link.springer.com/article/10.1007/s00204-017-2034-6/fulltext.html

Reference39 articles.

1. Alepee N, Bahinski A, Daneshian M et al (2014) State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology. Altex 31(4):441–477. doi: 10.14573/altex1406111

2. Ali N, Hosseini M, Vainio S, Taieb A, Cario-Andre M, Rezvani HR (2015) Skin equivalents: skin from reconstructions as models to study skin development and diseases. Br J Dermatol 173(2):391–403. doi: 10.1111/bjd.13886

3. Arnette C, Koetsier JL, Hoover P, Getsios S, Green KJ (2016) In vitro model of the epidermis: connecting protein function to 3D structure. Methods Enzymol 569:287–308. doi: 10.1016/bs.mie.2015.07.015

4. Chayapong J, Madhyastha H, Madhyastha R et al (2016) Arsenic trioxide induces ROS activity and DNA damage, leading to G0/G1 extension in skin fibroblasts through the ATM-ATR-associated Chk pathway. Environ Sci Pollut Res Int. doi: 10.1007/s11356-016-8215-7

5. Choudhury S, Ghosh S, Mukherjee S et al (2016) Pomegranate protects against arsenic-induced p53-dependent ROS-mediated inflammation and apoptosis in liver cells. J Nutr Biochem 38:25–40. doi: 10.1016/j.jnutbio.2016.09.001

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2. Protective effects of baicalin against phenylarsine oxide-induced cytotoxicity in human skin keratinocytes;Bioorganic Chemistry;2024-09

3. Loss of mutant p53 in HaCaT keratinocytes promotes cadmium-induced keratin 17 expression and cell death;Biochemical and Biophysical Research Communications;2024-05

4. Different immortalized keratinocyte cell lines display distinct capabilities to differentiate and reconstitute an epidermis in vitro;Experimental Dermatology;2023-12-03

5. The frontline of alternatives to animal testing: novel in vitro skin model application in drug development and evaluation;Toxicological Sciences;2023-09-13

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