Potent aneugenicity of 1-methylpyrene in human cells dependent on metabolic activation by endogenous enzymes
Author:
Funder
National Natural Science Foundation of China
Publisher
Springer Science and Business Media LLC
Subject
Health, Toxicology and Mutagenesis,Toxicology,General Medicine
Link
https://link.springer.com/content/pdf/10.1007/s00204-020-02933-w.pdf
Reference38 articles.
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2. Bendadani C, Meinl W, Monien BH, Dobbernack G, Florian S, Engst W, Nolden T, Himmelbauer H, Glatt HR (2014) Determination of sulfotransferase forms involved in the metabolic activation of the genotoxicant 1-hydroxymethylpyrene using bacterially expressed enzymes and genetically modified mouse models. Chem Res Toxicol 27:1060–1069. https://doi.org/10.1021/tx500129g
3. Bendadani C, Meinl W, Monien BH, Dobbernack G, Glatt HR (2014) The carcinogen 1-methylpyrene forms benzylic DNA adducts mouse and rat tissues in vivo via a reactive sulphuric acid ester. Arch Toxicol 88:815–821. https://doi.org/10.1007/s00204-013-1182-6
4. Bendadani C, Steinhauser L, Albert K, Glatt H, Monien BH (2016) Metabolism and excretion of 1-hydroxymethylpyrene, the proximate metabolite of the carcinogen 1-methylpyrene, in rats. Toxicology 366–367:43–52. https://doi.org/10.1016/j.tox.2016.08.006
5. Bi X, Sheng G, Feng Y, Fu J, Xie J (2005) Gas- and particulate-phase specific tracer and toxic organic compounds in environmental tobacco smoke. Chemosphere 61:1512–1522. https://doi.org/10.1016/j.chemosphere.2005.04.057
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