Hepatocyte spheroids as a competent in vitro system for drug biotransformation studies: nevirapine as a bioactivation case study-Reference-Cited by-同舟云学术

Hepatocyte spheroids as a competent in vitro system for drug biotransformation studies: nevirapine as a bioactivation case study

Published:2016-07-14 Issue:3 Volume:91 Page:1199-1211
ISSN:0340-5761
Container-title:Archives of Toxicology
language:en
Short-container-title:Arch Toxicol

Author:

Pinheiro Pedro F.,Pereira Sofia A.,Harjivan Shrika G.,Martins Inês L.,Marinho Aline T.,Cipriano Madalena,Jacob Cristina C.,Oliveira Nuno G.,Castro Matilde F.,Marques M. Matilde,Antunes Alexandra M. M.,Miranda Joana P.

Funder

Fundação para a Ciência e a Tecnologia

Publisher

Springer Science and Business Media LLC

Subject

Health, Toxicology and Mutagenesis,Toxicology,General Medicine

Link

http://link.springer.com/content/pdf/10.1007/s00204-016-1792-x.pdf

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2. Antunes AMM, Duarte MP, Santos PP et al (2008) Synthesis and characterization of DNA adducts from the HIV reverse transcriptase inhibitor nevirapine. Chem Res Toxicol 21(7):1443–1456. doi: 10.1021/tx8000972

3. Antunes AMM, Godinho AL, Martins IL, Justino GC, Beland FA, Marques MM (2010a) Amino acid adduct formation by the nevirapine metabolite, 12-hydroxynevirapine: a possible factor in nevirapine toxicity. Chem Res Toxicol 23(5):888–899. doi: 10.1021/tx900443z

4. Antunes AMM, Godinho AL, Martins IL et al (2010b) Protein adducts as prospective biomarkers of nevirapine toxicity. Chem Res Toxicol 23(11):1714–1725. doi: 10.1021/tx100186t

5. Antunes AMM, Novais DA, Ferreira da Silva JL et al (2011) Synthesis and oxidation of 2-hydroxynevirapine, a metabolite of the HIV reverse transcriptase inhibitor nevirapine. Org Biomol Chem 9(22):7822–7835. doi: 10.1039/c1ob06052j

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