27-Hydroxycholesterol inhibits trophoblast fusion during placenta development by activating PI3K/AKT/mTOR signaling pathway
Author:
Funder
Innovative Research Group Project of the National Natural Science Foundation of China
Publisher
Springer Science and Business Media LLC
Link
https://link.springer.com/content/pdf/10.1007/s00204-023-03664-4.pdf
Reference47 articles.
1. Alfaqih MA, Nelson ER, Liu W et al (2017) CYP27A1 loss dysregulates cholesterol homeostasis in prostate cancer. Can Res 77(7):1662–1673. https://doi.org/10.1158/0008-5472.Can-16-2738
2. Aplin JD, Myers JE, Timms K, Westwood M (2020) Tracking placental development in health and disease. Nat Rev Endocrinol 16(9):479–494. https://doi.org/10.1038/s41574-020-0372-6
3. Asghari A, Umetani M (2020) Obesity and cancer: 27-hydroxycholesterol, the missing link. Int J Mol Sci. https://doi.org/10.3390/Ijms21144822
4. Aye IL, Waddell BJ, Mark PJ, Keelan JA (2011) Oxysterols inhibit differentiation and fusion of term primary trophoblasts by activating liver X receptors. Placenta 32(2):183–191. https://doi.org/10.1016/j.placenta.2010.12.007
5. Bertolotti M, Del Puppo M, Corna F et al (2012) Increased appearance rate of 27-hydroxycholesterol in vivo in hypercholesterolemia: a possible compensatory mechanism. Nutr Metab Cardiovasc Dis 22(10):823–830. https://doi.org/10.1016/j.numecd.2011.02.009
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