Combinations of LXR and RXR agonists induce triglyceride accumulation in human HepaRG cells in a synergistic manner
Author:
Funder
Bundesinstitut für Risikobewertung
Publisher
Springer Science and Business Media LLC
Subject
Health, Toxicology and Mutagenesis,Toxicology,General Medicine
Link
http://link.springer.com/content/pdf/10.1007/s00204-020-02685-7.pdf
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2. Angrish MM, McQueen CA, Cohen-Hubal E, Bruno M, Ge Y, Chorley BN (2017) Editor’s highlight: mechanistic toxicity tests based on an adverse outcome pathway network for hepatic steatosis. Toxicol Sci 159:159–169. https://doi.org/10.1093/toxsci/kfx121
3. Angulo P (2002) Nonalcoholic fatty liver disease. N Engl J Med 346:1221–1231
4. Ankley GT, Bennett RS, Erickson RJ et al (2010) Adverse outcome pathways: a conceptual framework to support ecotoxicology research and risk assessment. Environ Toxicol Chem 29:730–741. https://doi.org/10.1002/etc.34
5. Antherieu S, Chesne C, Li R et al (2010) Stable expression, activity, and inducibility of cytochromes P450 in differentiated HepaRG cells. Drug Metab Dispos 38:516–525. https://doi.org/10.1124/dmd.109.030197
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