Evaluation of transcriptomic signature as a valuable tool to study drug-induced cholestasis in primary human hepatocytes

Author:

Parmentier Céline,Couttet Philippe,Wolf Armin,Zaccharias Thomas,Heyd Bruno,Bachellier Philippe,Uteng Marianne,Richert Lysiane

Funder

the Seventh Framework Programme – PredictIV “Profiling the toxicity of new drugs: A non-animal-based approach integrating toxicodynamics and biokinetics”

EU-EFPIA Innovative Medicine Initiative (IMI) project “Mechanism-Based Integrated Systems for the Prediction of Drug-Induced Liver Injury MIP-DILI”

Publisher

Springer Science and Business Media LLC

Subject

Health, Toxicology and Mutagenesis,Toxicology,General Medicine

Reference96 articles.

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2. Alam I, Ferrell LD, Bass NM (1996) Vanishing bile duct syndrome temporally associated with ibuprofen use. Am J Gastroenterol 91(8):1626–1630

3. Andrews E, Armstrong M, Tugwood J et al (2010) A role for the pregnane X receptor in flucloxacillin-induced liver injury. Hepatology 51(5):1656–1664. doi: 10.1002/hep.23549

4. Aoyama T, Yamano S, Waxman DJ et al (1989) Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine. J Biol Chem 264(18):10388–10395

5. Arrese M, Trauner M (2003) Molecular aspects of bile formation and cholestasis. Trends Mol Med 9(12):558–564

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