The modified IL-8 Luc assay, an in vitro skin sensitisation test, can significantly improve the false-negative judgment of lipophilic sensitizers with logKow values

The modified IL-8 Luc assay, an in vitro skin sensitisation test, can significantly improve the false-negative judgment of lipophilic sensitizers with logKow values > 3.5

Published:2020-10-17 Issue:2 Volume:95 Page:749-758
ISSN:0340-5761
Container-title:Archives of Toxicology
language:en
Short-container-title:Arch Toxicol

Author:

Kimura Yutaka,Fujimura Chizu,Aiba Setsuya^ORCID

Funder

Ministry of Economy, Trade and Industry

Ministry of Health, Labour and Welfare

Japanese Society for alternatives to Animal Experiments

Publisher

Springer Science and Business Media LLC

Subject

Health, Toxicology and Mutagenesis,Toxicology,General Medicine

Link

https://link.springer.com/content/pdf/10.1007/s00204-020-02934-9.pdf

Reference17 articles.

1. Barber RD, Harmer DW, Coleman RA, Clark BJ (2005) GAPDH as a housekeeping gene: analysis of GAPDH mRNA expression in a panel of 72 human tissues. Physiol Genomics 21(3):389–395. https://doi.org/10.1152/physiolgenomics.00025.2005

2. Edwards DR, Denhardt DT (1985) A study of mitochondrial and nuclear transcription with cloned cDNA probes. Changes in the relative abundance of mitochondrial transcripts after stimulation of quiescent mouse fibroblasts. Exp Cell Res 157(1):127–143

3. Gerberick GF, Vassallo JD, Foertsch LM, Price BB, Chaney JG, Lepoittevin JP (2007) Quantification of chemical peptide reactivity for screening contact allergens: a classification tree model approach. Toxicol Sci 97(2):417–427. https://doi.org/10.1093/toxsci/kfm064

4. Kim JH, Hu Y, Yongqing T et al (2016) CD1a on Langerhans cells controls inflammatory skin disease. Nat Immunol 17(10):1159–1166. https://doi.org/10.1038/ni.3523

5. Kimura Y, Fujimura C, Ito Y et al (2015) Optimization of the IL-8 Luc assay as an in vitro test for skin sensitization. Toxicol In Vitro 29(7):1816–1830. https://doi.org/10.1016/j.tiv.2015.07.006

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