Prediction of oral hepatotoxic dose of natural products derived from traditional Chinese medicines based on SVM classifier and PBPK modeling
-
Published:2021-03-13
Issue:5
Volume:95
Page:1683-1701
-
ISSN:0340-5761
-
Container-title:Archives of Toxicology
-
language:en
-
Short-container-title:Arch Toxicol
Author:
Li Size, Yu Yiqun, Bian Xiaolan, Yao Li, Li Min, Lou Yan-Ru, Yuan Jing, Lin Hai-shu, Liu Lucy, Han Bing, Xiang XiaoqiangORCID
Funder
National Natural Science Foundation of China Shanghai Science and Technology Innovation Fund Foundation of Shanghai Municipal Commission of Health and Family Planning
Publisher
Springer Science and Business Media LLC
Subject
Health, Toxicology and Mutagenesis,Toxicology,General Medicine
Reference50 articles.
1. Aiso M, Takikawa H, Tsuji K, Kagawa T, Watanabe M, Tanaka A, Sato K, Sakisaka S, Hiasa Y, Takei Y, Ohira H, Ayada M, Hashimoto E, Kaneko S, Ueno Y, Ohmoto K, Takaki A, Torimura T, Matsuzaki Y, Tajiri K, Yoneda M, Ito T, Kato N, Ikejima K, Mochida S, Yasuda H, Sakamoto N (2009) Analysis of 307 cases with drug-induced liver injury between 2010 and 2018 in Japan. Hepatol Res 49(1):105–110. https://doi.org/10.1111/hepr.13288 2. Albrecht W, Kappenberg F, Brecklinghaus T, Stoeber R, Marchan R, Zhang M, Ebbert K, Kirschner H, Grinberg M, Leist M, Moritz W, Cadenas C, Ghallab A, Reinders J, Vartak N, van Thriel C, Golka K, Tolosa L, Castell JV, Damm G, Seehofer D, Lampen A, Braeuning A, Buhrke T, Behr AC, Oberemm A, Gu X, Kittana N, van de Water B, Kreiling R, Fayyaz S, van Aerts L, Smedsrød B, Ellinger-Ziegelbauer H, Steger-Hartmann T, Gundert-Remy U, Zeigerer A, Ullrich A, Runge D, Lee SML, Schiergens TS, Kuepfer L, Aguayo-Orozco A, Sachinidis A, Edlund K, Gardner I, Rahnenführer J, Hengstler JG (2019) Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations. Arch Toxicol 93(6):1609–1637. https://doi.org/10.1007/s00204-019-02492-9 3. Bai S, Hu Z, Yang Y, Yin Y, Li W, Wu L, Fang M (2016) Anti-inflammatory and neuroprotective effects of triptolide via the NF-κB signaling pathway in a Rat MCAO model. Anat Rec (Hoboken) 299(2):256–266. https://doi.org/10.1002/ar.23293 4. Bischl B, Lang M, Kotthoff L, Schiffner J, Richter J, Studerus E, Casalicchio G, Jone ZM (2016) mlr: machine learning in R. J Mach Learn Res 17(170):1–5 5. Bolesta S, Haber SL (2002) Hepatotoxicity associated with chronic acetaminophen administration in patients without risk factors. Ann Pharmacother 36(2):331–333. https://doi.org/10.1345/aph.1A035
Cited by
51 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
|
|