S-(3-Aminobenzanthron-2-yl)cysteine in the globin of rats as a novel type of adduct and possible biomarker of exposure to 3-nitrobenzanthrone, a potent environmental carcinogen

Author:

Linhart IgorORCID,Hanzlíková Iveta,Mráz Jaroslav,Dušková Šárka

Funder

Ministry of Health of the Czech Republic - DRO (National Institute of Public Health - NIPH)

European Regional Development Fund, Integrated Operationa Programme

Publisher

Springer Science and Business Media LLC

Subject

Health, Toxicology and Mutagenesis,Toxicology,General Medicine

Reference30 articles.

1. Arlt VM (2005) 3-Nitrobenzanthrone, a potential human cancer hazard in diesel exhaust and urban air pollution: review of the evidence. Mutagenesis 20:399–410. doi: 10.1093/mutage/gei057

2. Arlt VM, Glatt H, Muckel E, Pabel U, Sorg BL, Seidel A, Frank H, Schmeiser HH, Phillips DH (2003a) Activation of 3-nitrobenzanthrone and its metabolites by human acetyltransferases, sulfotransferases and cytochrome P450 expressed in Chinese hamster V79 cells. Int J Cancer 105:583–592. doi: 10.1002/ijc.11143

3. Arlt VM, Stiborová M, Hewer A, Schmeiser HH, Phillips DH (2003b) Human enzymes involved in the metabolic activation of the environmental contaminant 3-nitrobenzanthrone: evidence for reductive activation by human NADPH:cytochrome P450 reductase. Cancer Res 63:2752–2761

4. Arlt VM, Stiborová M, Henderson CJ, Osborne MR, Bieler CA, Frei E, Martínek V, Sopko B, Wolf CR, Schmeiser HH, Phillips DH (2005) The environmental pollutant and potent mutagen 3-nitrobenzanthrone forms DNA adducts after reduction by NAD(P)H:quinone oxidoreductase and conjugation by acetyltransferases and sulfotransferases in human hepatic cytosols. Cancer Res 65:2644–2652. doi: 10.1158/0008-5472.CAN-04-3544

5. Arlt VM, Schmeiser HH, Osborne MR, Kawanishi M, Kanno T, Yagi T, Phillips DH, Takamura-Enya T (2006) Identification of three major DNA adducts formed by the carcinogenic air pollutant 3-nitrobenzanthrone in rat lung at the C8 and N2 position of guanine and at the N6 position of adenine. Int J Cancer 118:2139–2146. doi: 10.1002/ijc.21622

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