Salivary nitrate/nitrite and acetaldehyde in humans: potential combination effects in the upper gastrointestinal tract and possible consequences for the in vivo formation of N-nitroso compounds—a hypothesis

Author:

Eisenbrand Gerhard,Baum Matthias,Cartus Alexander T.,Diel Patrick,Engel Karl-Heinz,Engeli Barbara,Epe Bernd,Grune Tilman,Guth SabineORCID,Haller Dirk,Heinz Volker,Hellwig Michael,Hengstler Jan G.,Henle Thomas,Humpf Hans-Ulrich,Jäger Henry,Joost Hans-Georg,Kulling Sabine,Lachenmeier Dirk W.,Lampen Alfonso,Leist Marcel,Mally Angela,Marko Doris,Nöthlings Ute,Röhrdanz Elke,Roth Angelika,Spranger Joachim,Stadler Richard,Vieths Stefan,Wätjen Wim,Steinberg Pablo

Funder

Deutsche Forschungsgemeinschaft

Publisher

Springer Science and Business Media LLC

Subject

Health, Toxicology and Mutagenesis,Toxicology,General Medicine

Reference49 articles.

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2. Bellander T, Osterdahl BG, Hagmar L (1985) Formation of N-mononitrosopiperazine in the stomach and its excretion in the urine after oral intake of piperazine. Toxicol Appl Pharmacol 80:193–198. https://doi.org/10.1016/0041-008x(85)90075-4

3. BfR (2010) Gesundheitliche Bewertung von Acetaldehyd in alkoholischen Getränken. https://www.bfr.bund.de/cm/343/gesundheitliche_bewertung_von_acetaldehyd_in_alkoholischen_getraenken.pdf. Accessed 19 Feb 2022

4. Bulay O, Mirvish SS, Garcia H, Pelfrene AF, Gold B, Eagen M (1979) Carcinogenicity test of six nitrosamides and a nitrosocyanamide administered orally to rats. J Natl Cancer Inst 62:1523–1528

5. Burdock GA (2004) Fenaroli’s handbook of flavour ingredients. CRC Press, Boca Raton

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