Dissecting the predictive value of MAPK/AKT/estrogen-receptor phosphorylation axis in primary breast cancer to treatment response for tamoxifen over exemestane: a Translational Report of the Intergroup Exemestane Study (IES)—PathIES

Author:

Szijgyarto ZsoltORCID,Flach Koen D.,Opdam Mark,Palmieri Carlo,Linn Sabine C.,Wesseling Jelle,Ali Simak,Bliss Judith M.,Cheang Maggie Chon U.,Zwart Wilbert,Coombes R. Charles

Funder

Cancer Research UK

Pfizer UK

A Sister’s Hope

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology

Reference31 articles.

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2. Coombes RC, Hall E, Gibson LJ, Paridaens R, Jassem J, Delozier T, Jones SE, Alvarez I, Bertelli G, Ortmann O, Coates AS, Bajetta E, Dodwell D, Coleman RE, Fallowfield LJ, Mickiewicz E, Andersen J, Lonning PE, Cocconi G, Stewart A, Stuart N, Snowdon CF, Carpentieri M, Massimini G, Bliss JM, van de Velde C (2004) A randomized trial of exemestane after two to three years of tamoxifen therapy in postmenopausal women with primary breast cancer. N Engl J Med 350(11):1081–1092. https://doi.org/10.1056/NEJMoa040331

3. Early Breast Cancer Trialists’ Collaborative Group (EBCTCG) DM, Forbes JF, Bradley R, Ingle J, Aihara T, Bliss J, Boccardo F, Coates A, Coombes RC, Cuzick J, Dubsky P, Gnant M, Kaufmann M, Kilburn L, Perrone F, Rea D, Thürlimann B, van de Velde C, Pan H, Peto R, Davies C, Gray R (2015) Aromatase inhibitors versus tamoxifen in early breast cancer: patient-level meta-analysis of the randomised trials. Lancet 386 (10001):1341–1352. https://doi.org/10.1016/s0140-6736(15)61074-1

4. Speirs V, Viale G, Mousa K, Palmieri C, Reed SN, Nicholas H, Cheang M, Jassem J, Lonning PE, Kalaitzaki E, van de Velde CJ, Rasmussen BB, Verhoeven DM, Shaaban AM, Bartlett JM, Bliss JM, Coombes RC (2015) Prognostic and predictive value of ERbeta1 and ERbeta2 in the Intergroup Exemestane Study (IES)-first results from PathIESdagger. Ann Oncol 26(9):1890–1897. https://doi.org/10.1093/annonc/mdv242

5. Viale G, Giobbie-Hurder A, Regan MM, Coates AS, Mastropasqua MG, Dell’Orto P, Maiorano E, MacGrogan G, Braye SG, Ohlschlegel C, Neven P, Orosz Z, Olszewski WP, Knox F, Thurlimann B, Price KN, Castiglione-Gertsch M, Gelber RD, Gusterson BA, Goldhirsch A (2008) Prognostic and predictive value of centrally reviewed Ki-67 labeling index in postmenopausal women with endocrine-responsive breast cancer: results from Breast International Group Trial 1–98 comparing adjuvant tamoxifen with letrozole. J Clin Oncol 26(34):5569–5575. https://doi.org/10.1200/jco.2008.17.0829

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