Engineering targeted chromosomal amplifications in human breast epithelial cells

Author:

Springer Simeon,Yi Kyung H.,Park Jeenah,Rajpurohit Anandita,Price Amanda J.,Lauring Josh

Funder

U.S. Department of Defense

Flight Attendant Medical Research Institute

Allegheny Health Network

The Cleveland Foundation

National Cancer Institute

National Institute of General Medical Sciences

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology

Reference30 articles.

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3. Alt FW, Kellems RE, Bertino JR, Schimke RT (1978) Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells. J Biol Chem 253(5):1357–1370

4. Engelman JA, Zejnullahu K, Mitsudomi T, Song Y, Hyland C, Park JO, Lindeman N, Gale CM, Zhao X, Christensen J, Kosaka T, Holmes AJ, Rogers AM, Cappuzzo F, Mok T, Lee C, Johnson BE, Cantley LC, Janne PA (2007) MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 316(5827):1039–1043

5. Cowan KH, Goldsmith ME, Levine RM, Aitken SC, Douglass E, Clendeninn N, Nienhuis AW, Lippman ME (1982) Dihydrofolate reductase gene amplification and possible rearrangement in estrogen-responsive methotrexate-resistant human breast cancer cells. J Biol Chem 257(24):15079–15086

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