Abstract
Abstract
Purpose
Follow-up for breast cancer survivors consists of after care and surveillance. The benefits of routine surveillance visits remain debatable. In this study we compared the severity of locoregional recurrences (LRRs) and the subsequent risk of a distant metastasis (DM) between LRRs detected at routine and interval visits.
Methods
Women diagnosed with early breast cancer between 2003 and 2008 in one of the 15 participating hospitals, and who developed a LRR as first event after primary treatment, were selected from the Netherlands Cancer Registry (Cohort A). Chi-squared tests were used to compare the severity of routine- and interval-detected local recurrences (LRs) and regional recurrences (RRs), using tumor size, tumor grade, and number of positive lymph nodes. Data on the development of a subsequent DM after a LRR were available for a subset of patients (Cohort B). Cohort B was used to estimate the association between way of LRR-detection and risk of a DM.
Results
Cohort A consisted of 109 routine- and 113 interval-LRR patients. The severity of routine-detected LRs or RRs and interval-detected LRs or RRs did not significantly differ. Cohort B consisted of 66 routine- and 61 interval-LRR patients. Sixteen routine- (24%) and 17 (28%) interval-LRR patients developed a DM. After adjustment, way of LRR-detection was not significantly associated with the risk of a DM (hazard ratio: 1.22; 95% confidence interval: 0.49–3.06).
Conclusion
The current study showed that routine visits did not lead to less severe LRRs and did not decrease the risk of a subsequent DM.
Publisher
Springer Science and Business Media LLC
Reference37 articles.
1. World Cancer Research Fund, American Institute for Cancer Research (2018) Worldwide cancer data, Global cancer statistics for the most common cancers. https://www.wcrf.org/dietandcancer/cancer-trends/worldwide-cancer-data. Accessed 11 Nov 2021
2. van der Meer DJ, Kramer I, van Maaren MC, van Diest PJ, Linn SC, Maduro JH, Strobbe LJA, Siesling S, Schmidt MK, Voogd AC (2020) Comprehensive trends in incidence, treatment, survival and mortality of first primary invasive breast cancer stratified by age, stage and receptor subtype in the Netherlands between 1989 and 2017. Int J Cancer 148:2289–2303. https://doi.org/10.1002/ijc.33417
3. National GAU (2018) Early and locally advanced breast cancer: diagnosis and management. https://www.nice.org.uk/guidance/ng101. Accessed 10 Dec 2021
4. Khatcheressian JL, Hurley P, Bantug E, Esserman LJ, Grunfeld E, Halberg F, Hantel A, Henry NL, Muss HB, Smith TJ, Vogel VG, Wolff AC, Somerfield MR, Davidson NE (2013) Breast cancer follow-up and management after primary treatment: American Society of clinical oncology clinical practice guideline update. J Clin Oncol 31:961–965. https://doi.org/10.1200/JCO.2012.45.9859
5. Comprehensive Cancer Organisation the Netherlands (IKNL) (2020) Detectie nieuwe carcinoommanifestaties. https://www.oncoline.nl/borstkanker. Accessed 13 Feb 2020
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献