Randomized phase II clinical trial and biomarker analysis of paclitaxel plus epirubicin versus vinorelbine plus epirubicin as neoadjuvant chemotherapy in locally advanced HER2-negative breast cancer with TEKT4 variations

Author:

Jiang Yi-Zhou,Ge Li-Ping,Jin Xi,Fan Lei,He Min,Liu Yin,Chen Li,Zuo Wen-Jia,Wu Jiong,Liu Guang-Yu,Di Gen-Hong,Wang Zhong-Hua,Yu Ke-Da,Shao Zhi-MingORCID

Funder

National Natural Science Foundation of China

The Training Plan of Excellent Talents in the Shanghai Municipality Health System

The “Chen Guang” Project supported by the Shanghai Municipal Education Commission and Shanghai Education Development Foundation

The Shanghai Pujiang Program

The Training Plan of Excellent Talents of Fudan University Shanghai Cancer Center

The Shanghai Youth Excellent Academic Leader Program

The Municipal Project for Developing Emerging and Frontier Technology in Shanghai Hospitals

The Cooperation Project of Conquering Major Diseases in the Shanghai Municipality Health System

The Innovation Team of the Ministry of Education

The Shanghai Key Laboratory of Breast Cancer

Research Funding from Pfizer

the Shanghai Sailing Program

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology

Reference35 articles.

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2. Loibl S, Untch M, Burchardi N, Huober J, Sinn BV, Blohmer JU, Grischke EM, Furlanetto J, Tesch H, Hanusch C, Engels K, Rezai M, Jackisch C, Schmitt WD, von Minckwitz G, Thomalla J, Kummel S, Rautenberg B, Fasching PA, Weber K, Rhiem K, Denkert C, Schneeweiss A (2019) A randomised phase II study investigating durvalumab in addition to an anthracycline taxane-based neoadjuvant therapy in early triple negative breast cancer—clinical results and biomarker analysis of GeparNuevo Study. Ann Oncol Off J Eur Soc Med Oncol 30:1279–1288. https://doi.org/10.1093/annonc/mdz158

3. Balko JM, Cook RS, Vaught DB, Kuba MG, Miller TW, Bhola NE, Sanders ME, Granja-Ingram NM, Smith JJ, Meszoely IM, Salter J, Dowsett M, Stemke-Hale K, Gonzalez-Angulo AM, Mills GB, Pinto JA, Gomez HL, Arteaga CL (2012) Profiling of residual breast cancers after neoadjuvant chemotherapy identifies DUSP4 deficiency as a mechanism of drug resistance. Nat Med 18(7):1052–1059. https://doi.org/10.1038/nm.2795

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