Overexpression of TK1 and CDK9 in plasma-derived exosomes is associated with clinical resistance to CDK4/6 inhibitors in metastatic breast cancer patients

Author:

Del Re Marzia,Bertolini Ilaria,Crucitta Stefania,Fontanelli Lorenzo,Rofi Eleonora,De Angelis Claudia,Diodati Lucrezia,Cavallero Diletta,Gianfilippo Giulia,Salvadori Barbara,Fogli Stefano,Falcone Alfredo,Scatena Cristian,Naccarato Antonio Giuseppe,Roncella Manuela,Ghilli Matteo,Morganti Riccardo,Fontana Andrea,Danesi RomanoORCID

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology

Reference22 articles.

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2. Bagegni N, Thomas S, Liu N, Luo J, Hoog J, Northfelt DW, Goetz MP, Forero A, Bergqvist M, Karen J, Neumuller M, Suh EM, Guo Z, Vij K, Sanati S, Ellis M, Ma CX (2017) Serum thymidine kinase 1 activity as a pharmacodynamic marker of cyclin-dependent kinase 4/6 inhibition in patients with early-stage breast cancer receiving neoadjuvant palbociclib. Breast Cancer Res 19:123. https://doi.org/10.1186/s13058-017-0913-7

3. Berghuis AM, Koffijberg H, Prakash J, Terstappen LW, IJzerman M (2017) Detecting blood-based biomarkers in metastatic breast cancer: a systematic review of their current status and clinical utility. Int J Mol Sci. https://doi.org/10.3390/ijms18020363

4. Bjohle J, Bergqvist J, Gronowitz JS, Johansson H, Carlsson L, Einbeigi Z, Linderholm B, Loman N, Malmberg M, Soderberg M, Sundquist M, Walz TM, Ferno M, Bergh J, Hatschek T (2013) Serum thymidine kinase activity compared with CA 15-3 in locally advanced and metastatic breast cancer within a randomized trial. Breast Cancer Res Treat 139:751–758. https://doi.org/10.1007/s10549-013-2579-x

5. Chen P, Lee NV, Hu W, Xu M, Ferre RA, Lam H, Bergqvist S, Solowiej J, Diehl W, He YA, Yu X, Nagata A, VanArsdale T, Murray BW (2016) Spectrum and degree of CDK drug interactions predicts clinical performance. Mol Cancer Ther 15:2273–2281. https://doi.org/10.1158/1535-7163.MCT-16-0300

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