Chronopharmacokinetics of beta-receptor blocking drugs of different lipophilicity (propranolol, metoprolol, sotalol, atenolol) in plasma and tissues after single and multiple dosing in the rat

Author:

Lemmer Bj�rn,Winkler Horst,Ohm Thomas,Fink Markus

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology,General Medicine

Reference39 articles.

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2. Appelgren C, Borg KO, Elofsson R, Johansson KA (1974) Binding of adrenergic beta-receptor antagonists to human serum albumin. Acta Pharmacol Suecica 11:325?332

3. Borg KO, Fellenius E, Johansson R, Wallborg M (1975) Pharmacokinetic studies of metoprolol-(3H) in the rat and the dog. Acta Pharmacol Toxicol 36 Suppl V:104?115

4. Branch RA, Shand DG, Wilkinson GR, Nies AS (1973) The reduction of lidocaine clearance by d,l-propranolol: An example of hemodynamic drug interaction. J Pharmacol Exp Ther 184: 515?519

5. Brown HC, Carruthers SG, Johnston GD, Kelly JG, McAinsh J, McDevitt DG, Shanks RG (1976) Clinical pharmacologic observations on atenolol, a beta-adrenoceptor blocker. Clin Pharmacol Ther 20:524?534

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