Utilization of Glucocorticoids as Additives for Enhanced Sialylation of Fc-fusion Protein in CHO Cell Cultures

Author:

Han Hye-Jin,Lim Jin-Hyuk,Cha Hyun-Myoung,Lee Ji-Hun,Kim Dong-Il

Publisher

Springer Science and Business Media LLC

Subject

Biomedical Engineering,Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Reference26 articles.

1. Blondeel, E. J. M. and M. G. Aucoin (2018) Supplementing glycosylation: A review of applying nucleotide-sugar precursors to growth medium to affect therapeutic recombinant protein glycoform distributions. Biotechnol. Adv. 36: 1505–1523.

2. Weiss, P. and G. Ashwell (1989) The asialoglycoprotein receptor: properties and modulation by ligand. Prog. Clin. Biol. Res. 300: 169–184.

3. Jing, Y., Y. Qian, and Z. J. Li (2010) Sialylation enhancement of CTLA4-Ig fusion protein in Chinese hamster ovary cells by dexamethasone. Biotechnol. Bioeng. 107: 488–496.

4. Gramer, M. J., C. F. Goochee, V. Y. Chock, D. T. Brousseau, and M. B. Sliwkowski (1995) Removal of sialic acid from a glycoprotein in CHO cell culture supernatant by action of an extracellular CHO cell sialidase. Biotechnology (N Y). 13: 692–698.

5. Grilo, A. L. and A. Mantalaris (2019) The increasingly human and profitable monoclonal antibody market. Trends Biotechnol. 37: 9–16.

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