Author:
Ciceri Fabio, ,Beretta Luigi,Scandroglio Anna Mara,Colombo Sergio,Landoni Giovanni,Ruggeri Annalisa,Peccatori Jacopo,D’Angelo Armando,Cobelli Francesco De,Rovere-Querini Patrizia,Tresoldi Moreno,Dagna Lorenzo,Zangrillo Alberto, , , , , , , , , , , , , , , , , , , , ,
Abstract
We suggest the use of MicroCLOTS (microvascular COVID-19 lung vessels obstructive thromboinflammatory syndrome) as a new name for severe pulmonary coronavirus disease 2019 (COVID-19). We hypothesise that, in predisposed individuals, alveolar viral damage is followed by an inflammatory reaction and by microvascular pulmonary thrombosis. This progressive endothelial thromboinflammatory syndrome may also involve the microvascular bed of the brain and other vital organs, leading to multiple organ failure and death. Future steps in the understanding of the disease and in the identification of treatments may benefit from this definition and hypothesised sequence of events.
Publisher
College Of Intensive Care Medicine Of Australia And New Zealand